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Bills vs Rams Odds, Predictions and Tips

Week 14 delivers a coast-to-coast battle as the Buffalo Bills, fresh off a snowstorm blowout, clash with the Los Angeles Rams. With Josh Allen's MVP-level play and Matthew Stafford's comeback magic, this matchup pits AFC firepower against NFC grit. From head-to-head history to betting odds, here’s the full breakdown of this high-stakes encounter.

Heena Singh
Heena Singh

Last Updated: 2024-12-05

Chad Nagel

5 minutes read

Buffalo Bills defensive end Von Miller sacks Los Angeles Rams quarterback Matthew Stafford

Von Miller sacks Matthew Stafford//Getty Images

Week 14 is serving up a coast-to-coast clash that’s anything but ordinary. The Buffalo Bills are riding high – literally and figuratively – after obliterating the San Francisco 49ers 35-10 in a snowstorm so wild, Josh Allen threw a TD to himself. Now, the 10-2 juggernauts are trading snow boots for shades as they head to California to face the 6-6 Los Angeles Rams.

Matthew Stafford and the Rams pulled off their own plot twist last week, flipping a nap-inducing first half into a 21-14 comeback against the New Orleans Saints. SoFi Stadium might not have snow, but the stakes are icy: can the Bills keep flexing their AFC dominance, or will the Rams steal the spotlight? Settle in for a showdown where MVP swagger meets LA hustle. Kickoff’s at 4:25 p.m. ET. 

With the stakes this high, it’s the perfect time to check out the best NFL betting list offers.

Bills vs Rams Match Details

  1. Kickoff Time: 4:25 p.m. ET

  2. Location:  SoFi Stadium, Inglewood, California

  3. Last meeting: Rams 10-31 Bills (Sept. 9, 2022) 

Pre-game Odds and Win Probability: Bills Firm Favorites

  1. Bills: 1/2 (1.50) – 66,7%

  2. Draw: 14/1 (15.00) – 6,7%

  3. Rams: 7/4 (2.75) – 36,4%

    *Odds courtesy of Betway, subject to change

The Bills are storming into this matchup as 10-2 juggernauts, fresh off an AFC East crown and led by the unstoppable Josh Allen (who’s making an MVP case every week). Their well-oiled machine has been near-unstoppable, and they’re looking to flex that dominance again.

The Rams, at 6-6, are in survival mode. They’ve been scrappy, keeping it close in tight battles, but inconsistency has been their Achilles' heel. The odds suggest a long shot, but hey, stranger things have happened – especially under the SoCal lights.

Bills vs Rams Against the Spread (ATS):

  1. Bills -4 (-110)

  2. Rams +4 (-110)

The Bills roll into this clash as 4-point favorites, and let’s be real – it’s hard to argue against it. Last week’s 35-10 steamrolling of the Niners was a statement. Buffalo doesn’t just beat teams – they bury them. Betting on them to cover feels like money in the bank.

But hold up – here come the Rams, with a history of keeping games close. Their defense might bend like a yoga master, but it rarely snaps. Plus, those late-game theatrics (cue the Week 13 comeback against the Saints) might make the +4 spread appealing. 

Bills vs Rams Over/Under (O/U): 48.5

  1. Over (-115)

  2. Under (-105)

The Over looks tempting in this matchup, with Buffalo’s offense lighting up the scoreboard at 29.5 points per game and the Rams’ defense surrendering 21.9 on average. The Bills' passing game should have a field day against a Rams secondary that’s shown more holes than a practice net. Recent high-scoring outings by Buffalo only add fuel to the Over fire.

But don’t lock it in just yet. If the Rams’ defense tightens up and their offense stumbles, this could quickly become a grind-it-out battle. With Buffalo’s third-ranked defense in the mix, expect them to keep the Rams’ scoring in check.

Head-To-Head Record

The Rams and Bills are set for a rare showdown—just their third meeting since 2020. Buffalo’s been the boss in this matchup, winning their last two clashes and three straight since 2016. In fact, the Bills have claimed four of the last five meetings, making this matchup a tall order for LA.

Their most recent battle? A dominant 31-10 win by Buffalo in the 2022 season opener, fresh off the Rams’ Super Bowl triumph. The Bills covered the spread as 1-point favorites, though the total stayed under 52 points. 

Buffalo Bills (10-2)

  • Record: 10-2 
  • PCT: .833 
  • Home: 6-0 

The Bills are storming into Week 14 with a .833 win percentage, aiming to freeze out the competition. Offensively, Buffalo’s averaging 29.6 points per game and stacking up 4,231 total yards (that’s 352.6 per game!), they’re a dual-threat nightmare. 

Josh Allen? He’s practically his own highlight reel with 2,691 passing yards, 20 TDs, plus 21 team rushing touchdowns. Add 1,531 rushing yards, and you’ve got a team that can beat you in the air or on the ground.

Defensively, the Bills aren’t just about the numbers; they’re about sending messages. Opponents are held to 18.7 points per game, and the defense has snagged 13 interceptions like it’s their side hustle.

Los Angeles Rams (6-6)

  • Record: 6-6
  • PCT: .500 
  • Home: 3-3 

The Rams’ offense is serving up inconsistency—putting up 21.2 points per game and have churned out 4,185 total yards this season (348.8 per game). QB Stafford’s cannon arm is still sharp, with 2,983 passing yards, 17 TDs, and a solid 230.8 net passing yards per game. The run game, though? More of a sputter than a sprint—1,202 rushing yards (100.2 per game) and 10 trips to the end zone.

On defense, it’s been a rollercoaster. The Rams are giving up 24.2 points per game and have allowed 4,547 total yards (378.9 per game). Sure, they’ve matched their opponents with 10 interceptions, but that third-down efficiency? Opposing offenses are cashing in at nearly 40%—a stat that’s hurting LA in crunch time.

Special teams, however, are keeping the spark alive—averaging 13.4 yards per punt return and boasting a clutch 90% field goal success rate (16-of-21).

To keep their playoff hopes alive, LA needs to lock down their leaky rushing defense (144.2 yards allowed per game) and let Stafford cook.

Prediction: Buffalo Bills to Win

This matchup promises a showdown of offensive fireworks and defensive grit. Buffalo enters as 4-point favorites, backed by a high-octane offense averaging 29.5 points per game. Add their dominance at home and a potent passing attack, and the Bills covering the spread looks like a safe bet.

The Over 48.5 also holds appeal, with both teams capable of pushing the scoreboard. However, for the risk-takers, the Rams' 7/4 price offers a tempting underdog play. While LA has shown resilience in tight games, Buffalo’s red-hot form makes them the more reliable pick to win and control this contest.

Heena Singh
Heena SinghSports Writer

Heena Singh is your go-to NFL writer with a knack for turning the gridiron’s biggest moments into must-read stories. She brings a unique mix of sharp insights and quirky vibes, breaking down every touchdown, fumble, and post-game drama like a pro. A die-hard fan of the Kansas City Chiefs (and yes, Patrick Mahomes is her guy), Heena knows how to keep football fans hooked.