Philadelphia Eagles vs New York Giants Odds and Predictions

• Eagles to Cover (-2.5 Spread): Philadelphia is 10-6 against the spread and boasts a 7-1 home record. Their explosive offense and consistent defense make covering 2.5 points achievable. 
• Under 38.5 Total Points: Both teams have struggled to hit high totals recently. With the Eagles averaging a total of 45.6 and the Giants at 38.5, this matchup leans defensive. 
• Giants +2.5 Spread: New York has covered spreads in 5 of 11 games as underdogs of 2.5+ points this season. They may surprise with a tighter contest than expected. 

With solid predictions and numbers backing both sides, betting on over/under and spread outcomes could offer great value this weekend. 

Kenny Pickett's game against Washington didn’t go as planned, but the young QB managed to put the team in position to win. Despite several dropped passes, Pickett was effective, completing 10 of 15 passes for 143 yards and a 119.6 passer rating before exiting the game early.

It was later revealed that Pickett had been playing with broken ribs, an injury he sustained the week prior. Reports confirmed he took two painkiller shots to get through Sunday’s game. Eagles’ cornerback Darius Slay praised Pickett’s toughness, comparing his performance to Matthew Stafford’s, noting how hard it is to play through such an injury.

Despite being up 24-7 when Pickett exited, the Eagles continued to drive, but Pickett’s injury raised questions for next week. With playoffs approaching, fans are hoping to see Saquon Barkley break the rushing record, but it’s uncertain whether Jalen Hurts will return to the field after nearly three weeks off. If Hurts isn’t cleared, it leaves the Eagles with Tanner McKee, who impressed in relief of Pickett.

With Pickett’s injury still fresh, it’s clear the Eagles will need to weigh their options carefully as they prepare for the final game of the regular season.

The New York Giants weren’t about to let their playoff-less season drag them down. On Sunday, they stunned the Indianapolis Colts with a 45-33 win, defying the tanking narrative that’s surrounded them for weeks. Despite sitting out of playoff contention, the Giants delivered a solid performance on both sides of the ball, extending their lead from 21-6 in the second quarter and holding off a late rally from the Colts.

"We've had a lot of confidence in the people in our building," said head coach Brian Daboll. "It's a credit to the coaches, battling through it with the injured players. They work hard every day, are in early, and have extra meetings in December when you don't have a very good record. There’s a process we believe in, and they keep fighting through it. I’m just happy they can have a smile on their face after a win."

The victory, however, came at a price. The Giants dropped from the top spot of the 2025 NFL Draft order to No. 4, now behind teams like the Titans and Browns who are in desperate need of a quarterback. While draft implications might sting for fans hoping for the top pick, quarterback Drew Lock took the high road. “It’s not college,” he said. “We’re here to work every week. The season’s not over. We’ve got two games left, and we’re focused on winning them.”

For offensive tackle Jermaine Eluemunor, it’s about setting a foundation. “You’d rather your team fight for every inch than just take a loss," he explained. "It’s about culture. What’s the point of getting a top pick if the culture isn't right? We're trying to build something that leads into next year.”

So, while the Giants lost a shot at the first pick, they gained something bigger—respect. Their win against the Colts proves they still have fight left in them, setting the stage for a stronger future. It's all about laying the groundwork, and that’s exactly what they’re doing.

For the Giants, it all comes down to Daniel Jones. He’s thrown for 2070 yards this season, with 8 touchdowns and 7 interceptions. He’ll need to be sharp, but he’s got some serious weapons in Malik Nabers (104 receptions, 1140 yards, 6 TDs), Wan'Dale Robinson, and Darius Slayton to keep the Eagles' secondary on their toes.

But let’s not forget the Giants’ defense. Dexter Lawrence has 9 sacks, and Micah McFadden leads the team with 107 total tackles. With 43 sacks on the season, the Giants know how to get after the QB. If they can pressure Hurts, anything can happen.

The Eagles have the firepower, but the Giants are no slouches. If Hurts and Barkley do their thing, Philly should be in control. But with Jones and Nabers bringing the heat, and a hungry defense looking to disrupt Philly’s rhythm, don’t be shocked if the Giants pull off a surprise. Keep watching—this NFC East matchup’s gonna be lit!